Chuah YY, Lee YY, Tzeng WS, Shiue YL Inguinal ecchymosis, known as Stabler sign, is classically associated with retroperitoneal hemorrhage. However, imaging confirmation of the underlying mechanism is rarely demonstrated. We report a 33-year-old woman who developed progressive right inguinal ecchymosis one week after excisional surgery for fibrocystic breast nodules. Physical examination revealed extensive bruising over the right breast and a separate ecchymotic area in the r

Tagiling N, Simadibrata DM, Makharia GK, Sadgehi A, Moreira L, Leung WK, Kaplan GG, Leddin D, Metz G, Barkun AN, Lee YY Background And Aims Gastrointestinal (GI) and liver diseases are common and remain major contributors to global morbidity and mortality, with disease patterns increasingly shifting toward metabolic and functional etiologies. Anticipating these evolving challenges, the World Gastroenterology Organization (WGO), comprising 121 national and regional societies,

Simadibrata DM, Utari AP, Andarini L, Wijaya J, Hasanah NH, Cheng KY, Palsson OS, Sperber AD, Bangdiwala SI, Lee YY, Syam AF Background And Aims Disorders of gut-brain interaction (DGBI) significantly impact quality of life (QoL), healthcare utilization, and work productivity globally, yet data from Indonesia remain limited. This household face-to-face survey study aimed to investigate the prevalence and impact of DGBI on psychological distress, dietary habits, QoL, and healt

Tengku Alang TAI, Lee YY, Tan TS, Mokhtar AM Digital twins (DT) technology has shown considerable growth in recent years. Previous studies have examined technologies in a variety of areas, including health care. However, limited studies have attempted to provide a thorough discussion of strategies for the seamless integration of DT into health care, particularly in the context of interoperability of heterogeneous medical data. This review examines the underlying concept of DT

Siboni S, Sozzi M, Visaggi P, Kristo I, De Bortoli N, Tolone S, Marabotto E, Bernardi D, Schoppmann SF, Penagini R, Rogers B, Hobson A, Haworth J, Louie B, Lee YY, Tee V, Masuda T, Theodorou D, Triantafyllou T, Barcella B, Cusmai L, Puricelli M, Coletta M, Annese V, Savarino EV, Asti ELG, Gyawali CP Introduction According to Lyon 2.0, laryngopharyngeal symptoms (LPS) should undergo upfront pathophysiologic tests. The novel Milan score integrates esophagogastric junction (EGJ)

Hod K, Marasco G, Colecchia L, Cremon C, Barbaro MR, Cacciari G, Falangone F, Kagramanova A, Bordin D, Drug V, Miftode E, Fusaroli P, Mohamed SY, Ricci C, Bellini M, Rahman MM, Melcarne L, Santos J, Lobo B, Bor S, Yapali S, Akyol D, Sapmaz FP, Urun YY, Eskazan T, Celebi A, Kacmaz H, Ebik B, Binicier HC, Bugdayci MS, Yağcı MB, Pullukcu H, Kaya BY, Tureyen A, Hatemi İ, Koc ES, Sirin G, Calıskan AR, Bengi G, Alıs EE, Lukic S, Trajkovska M, Dumitrascu D, Pietrangelo A, Corradini

Simadibrata DM, Butt MF, Liu BD, Al-Fakhouri Z, Alomari L, Cheng KY, Palsson OS, Sperber AD, Bangdiwala SI, Lembo A, Lee YY Introduction Individuals with underweight or obesity may have altered gut-brain signaling. This study investigated the association between body mass index (BMI) and the prevalence and burden of disorders of gut-brain interaction (DGBI). Methods This cross-sectional analysis used the internet-based data from the Rome Foundation Global Epidemiology Study,

Chee D, Ya Ong CE, Tan DJH, Schattenberg JM, Ioannou GN, Huang DQ, HCC Policy Study Group No abstract available.

Wong RK, Fang X, Ghoshal UC, Kashyap PC, Mulak A, Lee YY, Sperber AD, Holtmann G Sociocultural determinants such as cultural norms, diet, and environmental factors, along with their effects on the gastrointestinal microbiome, can modify the risk to develop disorders of gut-brain interaction (DGBI). These factors also shape symptom perception and health care-seeking behaviors, and how society and health care providers respond to patients with DGBI. This document summarizes the

Leelakusolvong S, Chua TS, Quach DT, Ong AM, Syam AF, Galang AJG, Cheah WK, Dao HV, Sollano JD, Khaira KS, Kijdamrongthum P, Ambaras Khan R, Chirapongsathorn S, Lee YY Background And Aim Proton pump inhibitors (PPIs) are integral to managing many gastrointestinal conditions. However, the prevalent inappropriate PPI prescription across Southeast Asia (SEA) is concerning. Given the absence of locally tailored recommendations to inform clinical practice, this consensus document

Quach DT, Huynh TM, Galang AJG, Dao HV, Chirapongsathorn S, Kijdamrongthum P, Khan RA, Ong AM, Cheah WK, Khaira KS, Tan SF, Sollano J, Syam AF, Chua TS, Leelakusolvong S, Lee YY Despite widespread use, real-world evidence regarding proton pump inhibitor (PPI) prescribing and rationalization practices in Southeast Asia (SEA) remains limited; therefore, we aimed to characterize current prescribing behaviors and rationalization strategies among healthcare professionals in the re

GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators Background Enteric infectious diseases claim more than 1 million lives annually and are among the top ten causes of death in children younger than 5 years. Remarkable global investment has been dedicated to enteric infectious disease prevention and control; however, the shifting global health landscape is testing the continuance of progress. To evaluate the current status and guide future interventions,

Chuah YY, Ooi SW, Hsieh SP, Tzeng WS, Lee YY, Shiue YL, Tu CM, Liao CY Adult intussusception is an uncommon condition that usually indicates an underlying pathological lead point. Ileal perineurioma is an exceptionally rare benign peripheral nerve sheath tumor with limited gastrointestinal reports. We describe a 59-year-old woman presenting with acute severe abdominal pain, vomiting, and distension. Contrast-enhanced computed tomography demonstrated ileal intussusception with

Ayad ME, Yu S, El Shennawy S, Al Mowafy EA, Sahran NF, Elwalid-Jad R, Lee YY Background And Aim Postbiotics, preparations of inanimate microorganisms and/or their components with health benefits, may offer potential advantages in the management of IBS, but evidence remains limited. We conducted the first systematic review and meta-analysis to assess the efficacy and safety of postbiotics in adults with IBS. Methods PubMed, Scopus, Embase, and Web of Science were searched from

Sozzi M, Siboni S, Latorre-Rodriguez AR, Mittal SK, Marabotto E, Pasta A, Calabrese F, Andreatta E, Aldinio G, Coletta M, Penagini R, Lee YY, Ehab SAM, Tee V, Lee RH, Alcala-Gonzalez LG, Rogers B, Hennen MS, Haworth J, Patel A, Patel P, Masuda T, Coss-Adame E, Salvador R, Provenzano L, Nicoletti L, Piccirelli S, Pezzuto E, Tolone S, Asti E, Savarino EV, Gyawali CP Background High-resolution manometry (HRM) is increasingly used to assess risk of gastroesophageal reflux disease

Zheng F, Yang Y, Zhan Y, Zhang ZW, Lu G, Xie D, Zhang SM, Mageswary U, Lee YY, Liong MT Background Functional constipation is a common disorder of gut-brain interaction that substantially affects bowel function, psychological well-being, and quality of life. Probiotic supplementation represents a microbiota-targeted nutritional strategy for functional constipation, but associated host-response signals remain incompletely understood. Methods This single-center, randomized, dou

Quach DT, Liou JM, Gisbert JP, Leung WK, Moss SF, Fallone CA, Katelaris P, Schulz C, Kayamba V, Zhou L, Vu NTH, Vilaichone RK, Miftahussurur M, Setshedi M, Riquelme A, Yadegar A, Lee YY, Ishibashi F, Jung HY, Coelho LG, Suzuki H, Lee YC, Megraud F, Mahachai V, Sugano K, Malfertheiner P Background Despite increasingly refined diagnostic strategies and regularly updated treatment guidelines, real-world outcomes of Helicobacter pylori management remain variable. Antimicrobial re

Patcharatrakul T, Siah KTH, Syam AF, Nakajima A, Suzuki H, Lee YY, Hojo M, Rattanachaisit P, Pitisuttithum P, Quek S, Bai T, Ren YP, Nagahara A, Ong AM, Chen CL, Lu CL, Quach DT, Makharia GK, Wu JCY, Jung KW, Chuah KH, Zhong L, Rahman MM, Lee TH, Ghoshal UC, Hou X, Fang X, Xiao YL, Gonlachanvit S Background/Aims Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms,

Xu X, Shi Y, Tacke F, Wai-Sun Wong V, Li W, Sebastiani G, Newsome PN, Romero-Gomez M, Pan C, Castera L, Chai J, Kim W, Valenti L, Yilmaz Y, Win KM, Xu X, Ocama P, Ghazinyan H, Al Mahtab M, Hamid S, Lesmana CRA, Romeo S, Castellanos Fernandez MI, Yu X, Luukkonen PK, Takahashi H, Charatcharoenwitthaya P, Boursier J, Cua IH, Dao HV, Spearman CW, Bandara Dassanayake SU, Ayurzana M, Aghayeva G, Muthiah MD, Mendez-Sanchez N, Stedman CA, Alswat K, Sharara AI, Debzi N, Leite NC, Alkh

Lau SY, Kok VS, Tan SS, Adnan SD, Ng WL, Ang BH, Yaacob NY, Lee YY, Kaur S, Mohamed R, Wong PF, Lim LL, Letchumanan M, Vethakkan SR, Noor NM, Tan SF, Low TL, Kiew LB, Chan WK Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence-based, locally relevant recommendations for the preventi